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1

Inhibition of HIV-1 Tat-Dependent Trans Activation by Steric Block Chimeric 2‘- O -Methyl/LNA Oligoribonucleotides †

Arzumanov, Andrey, Walsh, Andrew P., Rajwanshi, Vivek K., Kumar, Ravindra, Wengel, Jesper, Gait, Michael J.

Journal:

Year:

2001

Language:

english

File:

PDF, 422 KB

english, 2001

2

Lung Delivery Studies Using siRNA Conjugated to TAT(48−60) and Penetratin Reveal Peptide Induced Reduction in Gene Expression and Induction of Innate Immunity

Moschos, Sterghios Athanasios, Jones, Simon Wyn, Perry, Mark Michael, Williams, Andrew Evan, Erjefalt, Jonas Sten, Turner, John James, Barnes, Peter John, Sproat, Brian Stephen, Gait, Michael John, Li

Journal:

Bioconjugate Chemistry

Year:

2007

Language:

english

File:

PDF, 506 KB

english, 2007

3

Use of Carbonyl Group Addition−Elimination Reactions for Synthesis of Nucleic Acid Conjugates

Zatsepin, Timofei S., Stetsenko, Dmitry A., Gait, Michael J., Oretskaya, Tatiana S.

Journal:

Bioconjugate Chemistry

Year:

2005

Language:

english

File:

PDF, 1.20 MB

english, 2005

4

A randomised trial of a brace for patellofemoral osteoarthritis targeting knee pain and bone marrow lesions

Callaghan, Michael J, Parkes, Matthew J, Hutchinson, Charles E, Gait, Andrew D, Forsythe, Laura M, Marjanovic, Elizabeth J, Lunt, Mark, Felson, David T

Journal:

Annals of the Rheumatic Diseases

Year:

2015

Language:

english

File:

PDF, 1.17 MB

english, 2015

5

With a biomechanical treatment in knee osteoarthritis, less knee pain did not correlate with synovitis reduction

Swaminathan, Vikram, Parkes, Matthew J, Callaghan, Michael J, O’Neill, Terence W, Hodgson, Richard, Gait, Andrew D, Felson, David T

Journal:

BMC Musculoskeletal Disorders

Year:

2017

Language:

english

File:

PDF, 906 KB

english, 2017

6

Mechanism of Copper Uptake from Blood Plasma Ceruloplasmin by Mammalian Cells

Ramos, Danny, Mar, David, Ishida, Michael, Vargas, Rebecca, Gaite, Michaella, Montgomery, Aaron, Linder, Maria C., Cobine, Paul A

Journal:

Year:

2016

Language:

english

File:

PDF, 2.16 MB

english, 2016

7

Solid-Phase Synthesis of Difficult Purine-Rich PNAs through Selective Hmb Incorporation: Application to the Total Synthesis of Cell Penetrating Peptide-PNAs

Tailhades, Julien, Takizawa, Hotake, Gait, Michael J., Wellings, Don A., Wade, John D., Aoki, Yoshitsugu, Shabanpoor, Fazel

Journal:

Frontiers in Chemistry

Year:

2017

Language:

english

File:

PDF, 961 KB

english, 2017

8

Modified oligoribonucleotides as site-specific probes of RNA structure and function

David J. Earnshaw, Michael J. Gait

Journal:

Year:

1998

Language:

english

File:

PDF, 581 KB

english, 1998

9

Use of the Fluorescent Nucleoside Analogue Benzo[g]quinazoline 2′-O-Methyl-β-D-ribofuranoside to Monitor the Binding of the HIV-1 Tat Protein or of Antisense Oligonucleotides to the TAR RNA Stem-Loop

Andrey Arzumanov, Frédéric Godde, Serge Moreau, Jean-Jacques Toulmé, Alan Weeds, Michael J. Gait

Journal:

Helvetica Chimica Acta

Year:

2000

Language:

english

File:

PDF, 315 KB

english, 2000

10

A New and Efficient Method for Synthesis of 5′-Conjugates of Oligonucleotides through Amide-Bond Formation on Solid Phase

Anna V. Kachalova, Dmitry A. Stetsenko, Elena A. Romanova, Vadim N. Tashlitsky, Michael J. Gait, Tatiana S. Oretskaya

Journal:

Helvetica Chimica Acta

Year:

2002

Language:

english

File:

PDF, 97 KB

english, 2002

11

Pyrenemethyl ara-Uridine-2′-carbamate: A Strong Interstrand Excimer in the Major Groove of a DNA Duplex

Natalia N. Dioubankova, Andrei D. Malakhov, Dmitry A. Stetsenko, Michael J. Gait, Pavel E. Volynsky, Roman G. Efremov, Vladimir A. Korshun

Journal:

Year:

2003

Language:

english

File:

PDF, 163 KB

english, 2003

12

ChemInform Abstract: A New “Native Ligation” Procedure for Peptide—Oligonucleotide Conjugation

Dmitry A. Stetsenko, Michael J. Gait

Journal:

Year:

2001

File:

PDF, 24 KB

2001

13

ChemInform Abstract: New Phosphoramidite Reagents for the Synthesis of Oligonucleotides Containing a Cysteine Residue Useful in Peptide Conjugation.

Dmitry A. Stetsenko, Michael J. Gait

Journal:

Year:

2002

File:

PDF, 28 KB

2002

14

ChemInform Abstract: Synthesis of Modified Nucleotide Building Blocks Containing Electrophilic Groups in the 2′-Position.

Anna V. Kachalova, Timofei S. Zatsepin, Elena A. Romanova, Dmitry A. Stetsenko, Michael J. Gait, Tatiana S. Oretskaya

Journal:

Year:

2002

File:

PDF, 31 KB

2002

15

ChemInform Abstract: Novel Uridin-2′-yl Carbamates: Synthesis, Incorporation into Oligodeoxyribonucleotides, and Remarkable Fluorescence Properties of 2′-Pyren-1-ylmethylcarbamate.

Vladimir A. Korshun, Dmitry A. Stetsenko, Michael J. Gait

Journal:

Year:

2002

Language:

english

File:

PDF, 38 KB

english, 2002

16

ChemInform Abstract: Fragment Coupling Approaches to the Synthesis of Peptide—Oligonucleotide Conjugates.

Dmitri A. Stetsenko, Michael J. Gait

Journal:

Year:

2002

File:

PDF, 26 KB

2002

17

LNA and α-L-LNA: Towards Therapeutic Applications

Jesper Wengel, Birte Vester, Lars Bo Lundberg, Stephen Douthwaite, Mads D. Soerensen, B. Ravindra Babu, Michael J. Gait, Andrey Arzumanov, Michael Petersen, Jakob T. Nielsen

Journal:

Year:

2004

File:

PDF, 69 KB

2004

18

The Synthesis of 2′-O-Methyl G-Clamp Containing Oligonucleotides and Their Inhibition of the HIV-1 Tat-TAR Interaction

Stephen C. Holmes, Michael J. Gait

Journal:

Year:

2004

File:

PDF, 60 KB

2004

19

Total Stepwise Solid-Phase Peptide-Oligonucleotide Conjugate Synthesis on Macroporous Polystyrene

Dmitry A. Stetsenko, Andrey D. Malakhov, Michael J. Gait

Journal:

Year:

2004

File:

PDF, 57 KB

2004

20

1,2-Diol and Hydrazide Phosphoramidites for Solid-Phase Synthesis and Chemoselective Ligation of 2′-Modified Oligonucleotides

Eugeny M. Zubin, Dmitry A. Stetsenko, Tatiana S. Oretskaya, Michael J. Gait

Journal:

Year:

2004

File:

PDF, 60 KB

2004

21

Chemical Methods for Peptide—Oligonucleotide Conjugate Synthesis

Dmitry A. Stetsenko, Michael J. Gait

Journal:

Year:

2005

File:

PDF, 8 KB

2005

22

Use of Carbonyl Group Addition—Elimination Reactions for Synthesis of Nucleic Acid Conjugates

Timofei S. Zatsepin, Dmitry A. Stetsenko, Michael J. Gait, Tatiana S. Oretskaya

Journal:

Year:

2005

File:

PDF, 8 KB

2005

23

Syntheses and Oligonucleotide Incorporation of Nucleoside Analogues Containing Pendant Imidazolyl or Amino Functionalities – The Search for Sequence-Specific Artificial Ribonucleases

Stephen C. Holmes, Michael J. Gait

Journal:

European Journal of Organic Chemistry

Year:

2005

Language:

english

File:

PDF, 205 KB

english, 2005

24

7-Deazaadenosine: Oligoribonucleotide building block synthesis and autocatalytic hydrolysis of base-modified hammerhead ribozymes

Frank Seela, Karin Mersmann, Jane A. Grasby, Michael J. Gait

Journal:

Helvetica Chimica Acta

Year:

1993

Language:

english

File:

PDF, 752 KB

english, 1993

25

In vitro evaluation of novel antisense oligonucleotides is predictive of in vivo exon skipping activity for Duchenne muscular dystrophy

Qingsong Wang, HaiFang Yin, Patrizia Camelliti, Corinne Betts, Hong Moulton, Hyunil Lee, Amer F. Saleh, Michael J. Gait, Matthew J. A. Wood

Journal:

The Journal of Gene Medicine

Year:

2010

Language:

english

File:

PDF, 471 KB

english, 2010

26

Comparison of controlled pore glass and Kieselguhr-polydimethylacrylamide composite as supports for solid-phase synthesis of 23-residue oligodeoxyribonucleotides in milligram amounts

Carlo Minganti, K.N. Ganesh, Brian S. Sproat, Michael J. Gait

Journal:

Analytical Biochemistry

Year:

1985

Language:

english

File:

PDF, 978 KB

english, 1985

27

Oligonucleotides containing 2′-O-[2-(2,3-dihydroxypropyl)amino-2-oxoethyl]uridine as suitable precursors of 2′-aldehyde oligonucleotides for chemoselective ligation

Eugeny M. Zubin, Dmitry A. Stetsenko, Timofei S. Zatsepin, Michael J. Gait, Tatiana S. Oretskaya

Journal:

Bioorganic & Medicinal Chemistry

Year:

2005

Language:

english

File:

PDF, 355 KB

english, 2005

28

Lipoplex and peptide-based strategies for the delivery of steric-block oligonucleotides

Sarah Resina, Saïd Abes, John J. Turner, Paul Prevot, Adrian Travo, Philippe Clair, Michael J. Gait, Alain R. Thierry, Bernard Lebleu

Journal:

International Journal of Pharmaceutics

Year:

2007

Language:

english

File:

PDF, 658 KB

english, 2007

29

DNA/RNA synthesis and labelling

Michael J. Gait

Journal:

Current Opinion in Biotechnology

Year:

1991

Language:

english

File:

PDF, 904 KB

english, 1991

30

Phosphoramidites and solid supports based on N-substituted 2,4-dihydroxybutyramides: universal reagents for synthesis of modified oligonucleotides

Natalia N. Dioubankova, Andrei D. Malakhov, Dmitry A. Stetsenko, Michael J. Gait, Vladimir A. Korshun

Journal:

Year:

2006

Language:

english

File:

PDF, 452 KB

english, 2006

31

Efficient conjugation and preferential DNA binding of oligonucleotides containing 2′-O-(2-oxoethyl)arabinouridine

Timofei S. Zatsepin, Yulia M. Ivanova, Dmitry A. Stetsenko, Michael J. Gait, Tatiana S. Oretskaya

Journal:

Tetrahedron Letters

Year:

2004

Language:

english

File:

PDF, 286 KB

english, 2004

32

Synthesis of DNA conjugates by solid-phase fragment condensation via aldehyde–nucleophile coupling

Timofei S. Zatsepin, Dmitry A. Stetsenko, Michael J. Gait, Tatiana S. Oretskaya

Journal:

Tetrahedron Letters

Year:

2005

Language:

english

File:

PDF, 158 KB

english, 2005

33

Synthesis of 2′-hydrazine oligonucleotides and their efficient conjugation with aldehydes and 1,3-diketones

Timofei S. Zatsepin, Michael J. Gait, Tatiana S. Oretskaya, Dmitry A. Stetsenko

Journal:

Tetrahedron Letters

Year:

2006

Language:

english

File:

PDF, 163 KB

english, 2006

34

The synthesis of peptide-oligonucleotide conjugates by a fragment coupling approach

Suzanne Peyrottes, Béatrice Mestre, Fabienne Burlina, Michael J. Gait

Journal:

Year:

1998

Language:

english

File:

PDF, 646 KB

english, 1998

35

Incompatibility of acid-labile 2′ and 5′ protecting groups for solid-phase synthesis of oligoribonucleotides

Chris Christodoulou, Sudhir Agrawal, Michael J. Gait

Journal:

Tetrahedron Letters

Year:

1986

Language:

english

File:

PDF, 152 KB

english, 1986

36

Novel spermine–Amino acid conjugates and basic tripeptides enhance cleavage of the hairpin ribozyme at low magnesium ion concentration

Karen Stolze, Stephen C Holmes, David J Earnshaw, Mohinder Singh, Dmitry Stetsenko, Donna Williams, Michael J Gait

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2001

Language:

english

File:

PDF, 243 KB

english, 2001

37

Synthesis of oligonucleotide 2′-conjugates via amide bond formation in solution

Anna V. Kachalova, Dmitry A. Stetsenko, Michael J. Gait, Tatiana S. Oretskaya

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2004

Language:

english

File:

PDF, 181 KB

english, 2004

38

Simultaneous Visualization of Vasopressin and Oxytocin mRNA- Containing Neurons in the Hypothalamus Using Non-Radioactive in situ Hybridization Histochemistry

Yosuke Ichimiya, Piers C. Emson, Chris Christodoulou, Michael J. Gait, Jerry L. Ruth

Journal:

Journal of Neuroendocrinology

Year:

1989

Language:

english

File:

PDF, 2.38 MB

english, 1989

39

Synthetic genes for human insulin

Gait, Michael J.

Journal:

Year:

1979

File:

PDF, 362 KB

1979

40

10.1038/35075244

Lilley, David M. J., Gait, Michael, Eckstein, Fritz

Journal:

Year:

2001

Language:

english

File:

PDF, 54 KB

english, 2001

41

Seamless joins

Gait, Michael J.

Journal:

Year:

1991

File:

PDF, 145 KB

1991

42

PtdIns(5)P activates the host cell PI3-kinase/Akt pathway during Shigella flexneri infection

Pendaries, Caroline, Tronchère, Hélène, Arbibe, Laurence, Mounier, Joelle, Gozani, Or, Cantley, Lewis, Fry, Michael J, Gaits-Iacovoni, Frédérique, Sansonetti, Philippe J, Payrastre, Bernard

Journal:

The EMBO Journal

Year:

2006

Language:

english

File:

PDF, 399 KB

english, 2006

43

Anti-HIV Activity of Steric Block Oligonucleotides

GABRIELA IVANOVA, ANDREY A. ARZUMANOV, JOHN J. TURNER, SANDRINE REIGADAS, JEAN-JACQUES TOULMÉ, DOUGLAS E. BROWN, ANDREW M.L. LEVER, MICHAEL J. GAIT

Journal:

Annals of the New York Academy of Sciences

Year:

2006

Language:

english

File:

PDF, 121 KB

english, 2006

44

Azimines as 1,3-dipoles

Challand, S. Richard, Gait, Stephanie F., Rance, Michael J., Rees, Charles W., Storr, Richard C.

Journal:

Journal of the Chemical Society Perkin Transactions 1

Year:

1975

Language:

english

File:

PDF, 807 KB

english, 1975

45

Synthesis of Modified Nucleotide Building Blocks Containing Electrophilic Groups in the 2′-Position

Kachalova, Anna V., Zatsepin, Timofei S., Romanova, Elena A., Stetsenko, Dmitry A., Gait, Michael J., Oretskaya, Tatiana S.

Journal:

Nucleosides Nucleotides & Nucleic Acids

Year:

2000

Language:

english

File:

PDF, 656 KB

english, 2000

46

2'-Functionalized Nucleic Acids as Structural Tools in Molecular Biology

Timofei S. Zatsepin, Michael J. Gait, Tatiana S. Oretskaya

Journal:

Year:

2004

Language:

english

File:

PDF, 306 KB

english, 2004

47

Conversion of PtdIns(4,5)P2 into PtdIns(5)P by the S.flexneri effector IpgD reorganizes host cell morphology

Niebuhr, Kirsten, Giuriato, Sylvie, Pedron, Thierry, Philpott, Dana J., Gaits, Frédérique, Sable, Julia, Sheetz, Michael P., Parsot, Claude, Sansonetti, Philippe J., Payrastre, Bernard

Journal:

The EMBO Journal

Year:

2002

Language:

english

File:

PDF, 339 KB

english, 2002

48

Applications of synthetic oligoribonucleotide analogues in studies of RNA structure and function

Jane A. Grasby, Clare E. Pritchard, Michael J. Gait

Journal:

Journal of Chemical Sciences

Year:

1994

Language:

english

File:

PDF, 1.10 MB

english, 1994

49

Cell penetrating peptide conjugates of steric block oligonucleotides

Bernard Lebleu, Hong M. Moulton, Rachida Abes, Gabriela D. Ivanova, Said Abes, David A. Stein, Patrick L. Iversen, Andrey A. Arzumanov, Michael J. Gait

Journal:

Advanced Drug Delivery Reviews

Year:

2008

Language:

english

File:

PDF, 467 KB

english, 2008

50

Endosome trapping limits the efficiency of splicing correction by PNA-oligolysine conjugates

Saïd Abes, Donna Williams, Paul Prevot, Alain Thierry, Michael J. Gait, Bernard Lebleu

Journal:

Journal of Controlled Release

Year:

2006

Language:

english

File:

PDF, 720 KB

english, 2006

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